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Fluorescent properties and

Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1,   Pages 106-115 doi: 10.15302/J-FASE-2017133

Abstract: order to investigate their fluorescent properties, photostability, cell toxicity and fluorescence imaging

Keywords： dehydroabietic acid-based diarylamine     DFT study     fluorescent probe     in vitro imaging    

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Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical

Ying Ma,Nanxue Zhang,Shi Wu,Haihui Huang,Yanpei Cao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 517-521 doi: 10.1007/s11684-016-0480-9

Abstract:

This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70.41%). The susceptibility to triple antibiotic ointment (neomycin/bacitracin/polymyxin B) and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.

Keywords： antimicrobial susceptibility/resistance     Propionibacterium acnes     topical antibiotics     in vitro study    

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In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water

Kaifeng RAO, Na LI, Mei MA, Zijian WANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1,   Pages 69-78 doi: 10.1007/s11783-013-0502-7

Abstract: In the present study, a battery of in vitro yeast bioassays and a cell bioassay, including antagonistic

Keywords： waste water     in vitro     recombinant yeast assay     ethoxyresorufin-O-deethylase (EROD)     receptor     endocrine    

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and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract: siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cell proliferation in vitro

Keywords： breast cancer     MID2     proliferation     overall survival     xenograft    

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IN VITRO ACTIVITY OF EXTRACTS OF FIVE MEDICINAL PLANT SPECIES ON PLANT PATHOGENIC FUNGI

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 635-644 doi: 10.15302/J-FASE -2020343

Abstract:

The antifungal effectiveness of extracts of five medicinal plant species was determined. The inhibitory activity of extracts of Eucalyptus tereticornis, Xanthium sibiricum, Artemisia argyi, Tupistra chinensis and Pyrola calliantha were evaluated against the mycelial growth of the plant pathogenic fungi Aspergillus niger, Botrytis cinerea, Penicillium digitatum, P. expansum, P. italicumand Rhizopus stolonifer. All plant extracts were prepared at 60°C using solvents (either water, 50% ethanol (v/v), 95% ethanol (v/v), ethyl acetate or petroleum ether). Fungicidal effects of all plants tested were confirmed. Different extracts from the same plant species gave different degrees of inhibition. All aqueous extracts had weak or no activity on all fungi tested. Ethyl acetate and 95% ethanol extracts from T. chinensis rhizomes gave greater inhibition and a broader spectrum inhibition than the other extracts. T. chinensis may have potential as a new natural fungicide and may be used for the preservation of agricultural and forestry products such as fruits and vegetables.

 

Keywords： Botrytis cinerea / food preservation / plant diseases / plant pathogenic fungi / Tupistra chinensis    

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evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 471-476 doi: 10.1007/s11684-014-0365-8

Abstract:

This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging

Keywords： type 2 diabetes mellitus     microalbuminuria     diffusion weighted imaging     diffusion tensor imaging     early-stage    

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Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 298-306 doi: 10.1007/s11705-022-2212-9

Abstract: Finally, the CA-CDs has been successfully applied for two-photon imaging of the pH in liver and kidneyImaging results showed that the pH value in kidney of diabetic mice was lower than that of the normal

Keywords： carbon dots     two-photon imaging     pH     diabetic mice    

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In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 239-247 doi: 10.1007/s11684-011-0123-0

Abstract: imaging is crucial for developmental biology and can further help to follow cell development/differentiationRecent advances in optical imaging techniques has facilitated tracing of the developmental dynamics ofThe zebrafish is an excellent model for imaging of hematopoiesis due to its transparent embryo at earlyIn this review, we summarize recent studies related to the non-invasive imaging of HSC transgenics,

Keywords： hematopoietic stem cell     hematopoiesis     in vivo imaging     transgenics     zebrafish    

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extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury in a new in vitro

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 307-318 doi: 10.1007/s11684-017-0547-2

Abstract:

Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence. The neuroprotective effects of extract (GBE) against several cerebral diseases have been reported in previous studies, but the underlying mechanisms of action are still unclear. Using a novel rat cortical capillary endothelial cell-astrocyte-neuron network model, we investigated the neuroprotective effects of GBE and one of its important constituents, Ginkgolide B (GB), against oxygen–glucose deprivation/reoxygenation and glucose (OGD/R) injury. In this model, rat cortical capillary endothelial cells, astrocytes, and neurons were cocultured so that they could be synchronously observed in the same system. Pretreatment with GBE or GB increased the neuron cell viability, ameliorated cell injury, and inhibited the cell apoptotic rate through Bax and Bcl-2 expression regulation after OGD/R injury. Furthermore, GBE or GB pretreatment enhanced the transendothelial electrical resistance of capillary endothelial monolayers, reduced the endothelial permeability coefficients for sodium fluorescein (Na-F), and increased the expression levels of tight junction proteins, namely, ZO-1 and occludin, in endothelial cells. Results demonstrated the preventive effects of GBE on neuronal cell death and enhancement of the function of brain capillary endothelial monolayers after OGD/R injury ; thus, GBE could be used as an effective neuroprotective agent for AIS/reperfusion, with GB as one of its significant constituents.

Keywords： acute ischemic stroke     Ginkgo bilobaextract     Ginkgolide B     network model     neuroprotection    

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Anefficient quadrature demodulator for medical ultrasound imaging

Hao ZHOU,Yin-fei ZHENG

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 301-310 doi: 10.1631/FITEE.1400205

Abstract: Quadrature demodulation is used in medical ultrasound imaging to derive the envelope and instantaneousIn this paper, we propose an efficient quadrature demodulation method for B-mode and color flow imagingIn the in vivo color flow imaging experiments, the time of the demodulation process was 5.66 ms and 3.36

Keywords： B-mode ultrasound imaging     Color flow imaging     Quadrature demodulation     Finite impulse response filter    

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Light field imaging: models, calibrations, reconstructions,and applications Review

Hao ZHU, Qing WANG, Jingyi YU

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 9,   Pages 1236-1249 doi: 10.1631/FITEE.1601727

Abstract: Light field imaging is an emerging technology in computationalphotography areas.Based on innovative designs of the imaging modeland the optical path, light field cameras not only recordFinally,open issues in light field imaging and long-term application prospectsin other natural sciences

Keywords： Light field imaging     Plenoptic function     Imaging model     Calibration     Reconstruction    

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Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging

Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 379-387 doi: 10.1007/s11684-011-0162-6

Abstract: Superparamagnetic iron oxide (SPIO) nanoparticles have become a popular strategy of cancer treatment and molecular imaging, targeted ligand-conjugated, and/or drug-loaded SPIO nanoparticles, as powerful tools for targeted imagingadvancements in the field of SPIO nanoparticles in terms of synthesis, targeted therapy, and cancer imaging

Keywords： nanoparticles     superparamagnetic iron oxide     targeted therapy     molecular imaging     cancer    

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A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 103-111 doi: 10.1007/s11705-021-2064-8

Abstract: Uridine diphosphate (UDP)-glucuronosyltransferases (UGTs) are enzymes involved in the biotransformation of important endogenous compounds such as steroids, bile acids, and hormones as well as exogenous substances including drugs, environmental toxicants, and carcinogens. Here, a novel fluorescent probe BDMP was developed based on boron-dipyrromethene (BODIPY) with high sensitivity for the detection of UGT1A8. The glucuronidation of BDMP not only exhibited a red-emission wavelength (λex/λem = 500/580 nm), but also displayed an excellent UGT1A8-dependent fluorescence signal with a good linear relationship with UGT1A8 concentration. Based on this perfect biocompatibility and cell permeability, BDMP was successfully used to image endogenous UGT1A8 in human cancer cell lines (LoVo and HCT15) in real time. In addition, BDMP could also be used to visualize UGT1A8 in tumor tissues. These results suggested that BDMP is a promising molecular tool for the investigation of UGT1A8-mediated physiological function in humans.

Keywords： UDP-glucuronosyltransferase 1A8     fluorescent probe     subtype selectivity     fluorescence imaging    

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of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging

Frontiers of Medicine   Pages 993-1005 doi: 10.1007/s11684-023-0989-7

Abstract: The functional magnetic resonance imaging (fMRI) data were analyzed for investigating brain changes induced

Keywords： acupuncture     migraine     fMRI     metabolome     proteome    

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Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

Xiaoqing REN,Hongwei CHEN,Victor YANG,Duxin SUN

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 253-264 doi: 10.1007/s11705-014-1425-y

Abstract: studied, iron oxide nanoparticles have advantages since IONPs have good biocompatibility and spatial imagingThis review is focused on the IONP-based nanotheranostics for cancer imaging and treatment.applications of IONP nanotheranostics is summarized, which includes IONP-based diagnosis, magnetic resonance imaging(MRI), multimodal imaging, chemotherapy, hyperthermal therapy, photodynamic therapy, and gene delivery

Keywords： theranostics     iron oxide nanoparticles     MRI     drug delivery     photothermal therapy     photodynamic therapy    

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Title Author Date Type Operation

Fluorescent properties and

Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG

Journal Article

Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical

Ying Ma,Nanxue Zhang,Shi Wu,Haihui Huang,Yanpei Cao

Journal Article

In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water

Kaifeng RAO, Na LI, Mei MA, Zijian WANG

Journal Article

and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

IN VITRO ACTIVITY OF EXTRACTS OF FIVE MEDICINAL PLANT SPECIES ON PLANT PATHOGENIC FUNGI

Journal Article

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Journal Article

Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Journal Article

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Journal Article

extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury in a new in vitro

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Journal Article

Anefficient quadrature demodulator for medical ultrasound imaging

Hao ZHOU,Yin-fei ZHENG

Journal Article

Light field imaging: models, calibrations, reconstructions,and applications

Hao ZHU, Qing WANG, Jingyi YU

Journal Article

Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging

Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen

Journal Article

A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living

Journal Article

of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging

Journal Article

Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

Xiaoqing REN,Hongwei CHEN,Victor YANG,Duxin SUN

Journal Article